Myelodysplastic syndrome: validation of flow cytometry multilineage score system

Flow cytometry immunophenotyping for diagnosis of myelodysplastic syndrome.

Diagnostic utility of flow cytometry in low-grade myelodysplastic syndromes: a prospective validation study.

BACKGROUND The diagnosis of myelodysplastic syndromes is not always straightforward when patients lack specific diagnostic markers, such as blast excess, karyotype abnormality, and ringed sideroblasts. DESIGN AND METHODS We designed a flow cytometry protocol applicable in many laboratories and verified its diagnostic utility in patients without those diagnostic markers. The cardinal parameter...

The Use of Flow Cytometry in Myelodysplastic Syndromes: A Review

Myelodysplastic syndromes (MDSs) are a heterogeneous group of hematopoietic stem cell diseases categorized by dysplasia in one or more hematopoietic cell lineages, as well as cytopenia and functional abnormalities in bone marrow cells. Several MDS classification methods have been proposed to categorize the disease and help professionals better plan in patients' treatment. The World Health Organ...

Diagnostic Utility of Flow Cytometry in Myelodysplastic Syndromes

The pathological hallmark of myelodysplastic syndromes (MDS) is marrow dysplasia, which represents the basis of the WHO classification of these disorders. This classification provides clinicians with a useful tool for defining the different subtypes of MDS and individual prognosis. The WHO proposal has raised some concern regarding minimal diagnostic criteria particularly in patients with norma...

Flow Cytometry in the Diagnosis of Myelodysplastic Syndromes

BACKGROUND Confirming diagnosis of myelodysplastic syndromes (MDS) is often challenging. Standard diagnostic methods are cytomorphology (CM) and cytogenetics. Multiparameter flow cytometry (MFC) is upcoming in MDS diagnostic work up, comparability and investigator experiences are critical. Myeloid nuclear differentiation antigen (MNDA) in myelomonocytic cells might be expressed more weakly in p...